A vascular access in the form of internal jugular catheter / femoral vein catheter / AV fistula / AV graft is required. A plasmafilter is used for the procedure. Haemodialysis machine with the blood pump and blood lines are used. Replacement fluid is infused into the blood line. Anticoagulation is used appropriately.
Some of the conditions requiring plasmapheresis are anti GBM disease, Hemolytic Uraemic Syndrome / Thrombotic thrombocytopenic purpura, cryoglobulinemia, some vasculitic processes, recurrent FSGS in renal transplant, sensitized patients waiting for renal transplant.